easyLSEA: Lipid Set Enrichment Analysis with Dual KS and 'fgsea' Engines

Provides biology-aware lipid set enrichment analysis (LSEA) for lipidomics data using dual engines: the Kolmogorov-Smirnov test and the fast gene set enrichment algorithm from the 'fgsea' package. Annotates lipids into biological groups at three levels (lipid class, LIPID MAPS category, functional category) and tests for coordinated directional shifts between conditions. Includes fatty acid chain analysis with trend plots weighted by lipid abundance (Spearman rank correlation, configurable smoothing), wide-format chain position output (sn-1, sn-2, sn-3, sn-4), annotation confidence filtering, and export utilities for reproducible reporting in CSV, 'Excel', and PDF formats. Vignettes are available in English and Spanish. Methods are based on Subramanian et al. (2005) <doi:10.1073/pnas.0506580102> and Korotkevich et al. (2021) <doi:10.1101/060012>.

Version: 0.2.1
Depends: R (≥ 4.1.0)
Imports: ggplot2, withr
Suggests: fgsea, knitr, openxlsx, rmarkdown, spelling, testthat (≥ 3.0.0)
Published: 2026-06-16
DOI: 10.32614/CRAN.package.easyLSEA (may not be active yet)
Author: David Guardamino Ojeda ORCID iD [aut, cre]
Maintainer: David Guardamino Ojeda <david.guardamino at gmail.com>
BugReports: https://github.com/DavidGO464/easyLSEA/issues
License: MIT + file LICENSE
URL: https://github.com/DavidGO464/easyLSEA
NeedsCompilation: no
Language: en-US
Materials: README
CRAN checks: easyLSEA results

Documentation:

Reference manual: easyLSEA.html , easyLSEA.pdf
Vignettes: Introducción a easyLSEA (source, R code)
Introduction to easyLSEA (source, R code)

Downloads:

Package source: easyLSEA_0.2.1.tar.gz
Windows binaries: r-devel: not available, r-release: not available, r-oldrel: not available
macOS binaries: r-release (arm64): not available, r-oldrel (arm64): not available, r-release (x86_64): not available, r-oldrel (x86_64): not available

Linking:

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